Prof. Gad Rennert is the Director of the Clalit National Israeli Cancer Control Center and Professor and Chairman of the Department of Community Medicine Carmel Medical Center
Haifa, Israel. He is currently seeking to understand the causes and variable behavior of breast cancers in different populations. Efforts are ongoing to identify differences in tumor molecular characteristics, inherited genetic mutations, and environmental exposures in an ethnically diverse group of breast cancer patients.
This work is providing new insight into the causes of breast cancer that influence outcomes in Middle Eastern populations and may lead to new prevention and treatment strategies.
Breast cancer outcomes and response to treatment are affected by multiple factors, including demographic characteristics (such as age at diagnosis and ethnic group), environmental exposures (such as reproductive patterns and obesity), and biological/genetic characteristics of the patient.
Dr. Rennert's BCRF research aims to identify sub-sets of women with differing patterns of disease behavior, such as recurrence in the same or contralateral (opposite) breast, metastases (and site of metastases), and death due to breast cancer.
He is studying these sub-groups for differences in tumor molecular characteristics, inherited genetic mutations, and environmental exposures in an effort to better understand the causes of breast cancer.
The study population of more than 8,000 women with breast cancer includes Jewish women of many different origins (Ashkenazi, Sephardi) as well as Arab women of different origins, religions (Moslem, Christian, Druze) and different dwelling types (representing different risk exposure patterns).
The high degree of variability in the rates of cancer between these groups, as well as a different distribution of tumor types will potentially enable us to understand the biological or behavioral background of the variation.
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